Diabetic neuropathy is a difficult condition where the peripheral nerves, typically in the toes and the feet, are affected by glucose in a way that they stop functioning either to not feel or to feel too much and to have pain.

You can think of the nerves a little bit like a wire whose cover has been partially eroded and there’s still current going down that wire, and so early on you get sparking between the different parts of the wire, whether or not covered by insulation properly. And that will cause tingling in your toes, and that’s the most typical beginning of neuropathy.

When you know it’s diabetic, it typically will begin in the largest toes or usually the big toe; it will be symmetrical in both feet. It will start to involve the other toes. It will slowly work its way up to the foot as it progresses as sometimes you see it up the knee or even higher.

And so the painful neuropathies are --